Life expectancy in people with severe mental illness (SMI) is between 15 to 20 years less than that of the general population, a gap that is similar to that experienced by Indigenous Australians. The vast majority of excess deaths are due to chronic physical disease, including cancer. The team undertaking this study, led by Prof Steve Kisely at the University of Queensland, has undertaken previous research that has shown that cancer incidence rates in people with SMI are similar to those in the general population, but that cancer mortality is higher. Possible explanations include: 1) Poor cancer screening participation rates in those with SMI; 2) delays in diagnosis leading to more advanced disease at diagnosis; & 3) sub-optimal post-diagnosis management. I will be leading the qualitative component of this large study that will further investigate these issues using a range of mixed data collection methods. In focus groups, we will investigate the experience of people with SMI and colorectal cancer (and their carers) in relation to the barriers and enablers to screening, diagnosis and optimal care. The focus groups will ensure that the voices of people with lived experience of SMI and bowel cancer are heard and contribute to helping to understand what is happening when people are diagnosed and access care. The overall results of the study may indicate the actions required to decrease inequity and enhance this marginalised group’s access to optimal care, thereby improving their health outcomes. Findings may also have implications for other disadvantaged groups and other health problems.